The .243 is a great gun for pronghorn... I used my 6mm with 90g ballistic tips to take the one you see in my avatar.
I also have used my 6mm to take around 6 deer in the past few years.
I have not stretched my shots nad have kept them under 200yrds.
The antlope fell to one shot behind the shoulder, and a large mule doe dropped in her tracks at 160+yrds.
As everyone has said, keep your shots reasonable, and put the bullet in the right place you won't be tracking any longer than anything else. I have seen deer lost with .30-06 and .308's!
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It doesn't matter what you hunt, as long as you hunt
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Member - AOPA - Lloydminster & Area Archery Assoc. - Life Member NAHC - IBEP Instructor
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