[Jack]

Vickyjo, welcome to Huntchat.
You've gotten some good advice so far, and I don't know that mine will be any different.
As to calibers, 25-06 is great for deer and antelope, but not enough for elk, IMO. Maybe the 270 would be better if elk are in the mix.
Now, you mentioned a left hand rifle- you'll find that lefty bolt actions aren't made in as many calibers as righy bolt guns, but, you'll find 270 lefty's.
I will point out a law of physics that may effect you: all things equal (same caliber, bullet weight, etc.) light rifles kick more than standard weight rifles.
Evan pointed this out, and I've noticed it, too...in some of the really lightweight rifles, a relatively light kicking caliber can whack you pretty good.
So, for a lefty, I'll recommend a standard weight bolt gun in 270. Avoid the lightweight rifles, even though they're tempting.
Shoot 130 grain bullets for deer and antelope, and switch to 150 grain bullets for elk.
And don't scimp on a scope, either- a good scope is just as important as a good rifle.