If your talking about a 10-22 you can change barrels on them very easily. There is only 1 screw that holds the barrel to the action. If you do this I would recomand that you clean the hole in the recever out good with acohal and clean the barrel off where it fit in the same way. Then when you put in the new barrel put a small amount of epoxy on the barrel. This will remove all slop and in prove accuracy. If you are talking about a centerfire rifle, you can run into head space problem if you try to fit your own barrel and I would recomand that you have a gunsmith put the barrel in the action for safity.
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Catfish
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