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The round you want is the 45 acp. The 40 is more popular now only because the police use it. Most civillians will pick up what the most recent trend is in calibers, and think if it is good enough for the police then it must be good. The 45 is alot easier to shoot in my opinion. I have always worried about if it would penetrate enough though? The 45 acp costs more to shoot then the 40 or 9mm. The 45 is also used usually in a bigger frame firearm which people sometimes complain about. The 40 is snappy and can be hard for follow up shots. It is the middle ground between the 9mm and 45acp. It provides 16 rounds and a little more power than the 9mm. Overall shot placement is the key and most calibers 9mm and above are acceptable for self-defense. The 45 would be a excellent firearm and has a excellent street record. I prefer the glock 21 over the 1911's but thats just me. Esox357
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