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I honestly think the .243Win. says it all. It's about the only varmint caliber I know of that will negate the benefits of a .22-250Rem. I have both and think you might do better to go the other way, say a .222Rem. I just don't think the day of the .222Rem. has come and gone. It's still a pure joy to own and shoot. Just one mans opinion. Best wishes.
Cal - Montreal
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