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Well I sure wouldn't recommend a 22 caliber for deer, their small lightweight bullets don't expand to make what I'd call a devastating wound channel. I myself am a fan of the ought six cartridges. 25-06 and 30-06 are about as good as they get. The 25 is good for whitetail especially, but a 30-06 would be my choice for mulies. The 25-06 has the power to take deer(especially whitetail) down beyond 400 yards without a problem at all, but when it comes to long range open landscape mule deer hunting, the 30-06 shoots a heavier bullet with an outstanding flat trajectory to the range you might be encountering on the plains.
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