I can see some use for a 22-250AI but it depends what you want it for. If I was shooting 55grainers, then I'd stay with a 22-250. But if I couple a fast twist barrel with heavy for caliber bullets, the AI would make a great long range hunting rig for varmints. Use an 85 grain to 100 grain Wildcat HP bullet and you've got a ballistic coefficient in the .5 range which is pretty darn good. A flying telephone pole...
My current 22-250 is getting a bit worn and may rechamber to the AI.
A concern is feeding difficulties due to the sharp shoulder on the improved cartridge.
I'd have to get a 223 then to cover me out to 400 yards or so and the 22-250AI from there to 1K yards.
Thanks Highthrill. Would you say it's even better than the 270win?

Is that 260rem chambered in one of those crappy remingtons?