Some revolvers come with interchangeable cylinders- one cylinder for 22 magnum, the other for 22lr. As has been pointed out.
In the 22lr cylinder, you can use shorts, longs, or long rifles cartridges.
Cartridge dimensions of the 2 cartridges are different - 22 magnum case body diameter is larger than that for the 22lr.
Now, if you fire a 22lr cartridge (of any kind) in a 22 magnum chamber, you will most likely have a split case, releasing gas back thru the action, as well as dirtying up the chamber......
A bad scenario, and one to be avoided!
DO NOT fire 22lr cartidges in 22 magnum chambers.
So, the short answer is definitely NO, unless you have an interchangeable cylinder revolver.
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