Well I guess I would have to say that I think Dom has it about right, but I might actually go with a .300 Weatherby in the middle instead of the .30-06 as it packs a little more punch in the gray areas and has more reach for moutnain or plains game.
So:
.222 Rem.
.300 Wby (but I would take the .30-06 and be happy)
.375 H&H
1000 pound elephant! Are you on a calf hunt?
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