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While my first hand knowledge of the 10mm is limited (I haven't fired one either) I am somewhat familiar with it. The 10mm would do well for self defense but be mindfull that the main downfall of the cartridge was that the weapons that it was/is chambered for at first didn't seem to like it very well hence it's downfall. Choose the weapon carefully and I suggest firing on of the particular models in which you are wanting or at least ask someone who owns one how it is handling.
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