Let me first say that the 22lr is not my first choice for shooting anything larger than a Racoon. Now that being said I have shot several yotes with a 22lr and I have dispathched a few of the several that I shot but never with a heart lung shot. Mine have always been head shots, always less than 30 yards. I have also bounced 22lr slugs off the skulls of three coyotes. I would never take a heart lung shot at a coyote with anything less than a 22 Hornet. The 22lr may kill it in an hour or two, day or two it may kill it on the spot but why take the chance! I'm sure that you have shot squirrels that weigh less than 2 pounds that did not die on the spot with your 22lr. So why would you intentionally go after a coyote that on the light side weighs ten times that of the the squirrel and may weigh 25 times as much? No... give the animal some respect and use a larger weapon to hunt coyotes with.
Kirkned