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22lr perhaps not but with a good 22 mag then i would have to say yes but at a reasonable range to ensure a good shot with a proper bullet. a 22 mag with neutralize beavers at 120 yds like you wouldn't believe. are you coyote hunting,trapping, or just in case you need for self defense against one? my personal opinion is a good shot with a 22lr at no further that 50yds can cleanly kill a yote but do not try a heart/lung shot b/c they will run and suffer too long. if you are trapping then yes a point blank shot for mercy will do the job. for protection while you are squirrel hunting then i say yes but as with all creatures i would avoid yotes if they pose you no harm. just my 2 cents
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