Very good caliber that seems to have been overshadowed by the 270 and 30-06 for its existance, not to mention the 7mm rem mag. Still a fair amount of ammo made for the 280, and in a store with a good supply you should be able to find some. As far as comparisons, it'll do anything a 270 and 30-06 will do. If you're interested, buy it. You won't be sorry.
gd