The favorite cartridge of poachers around here (and we have a lot) is the .22 LR. Also I know a few fellows who take pride in killing deer with the .222 and .223. So yes, it will kill a deer.
I have killed one with a 5.56 but it was hardly a sporting context, I was testing ammo and gathering meat for a barbeque at a military site. Neither me or the deer was immediately impressed though she did finally become convinced that she was invited for dinner.
I would tend to agree with Rocky's description above and cannot do better. To be sure, placement is critical with any cartridge but I like to do all my hunting before I shoot.
Then again, I don't want to rain on anyone's parade. I never went Deep Sea fishing with a fly rod but I guess it could be done - if that is your bag, more power to you!
Riposte
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The will to win is nothing, without the will to prepare.
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