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I think Rocky's given you excellent advice.
I've used a 308 (among other rifles) for deer since 1971. The bullet I have used since the beginning is a 165 grain Nosler Partition, and I've never had reason to change. The first shot has always worked, from any angle.
I have only been able to recover 1 expanded bullet using the 165 Partition, and that bullet penetrated 33 inches, including some bone, so I doubt you need a heavier bullet.
Rocky's listed some good powders to look at. I would add AA2520 powder to that list.
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Jack@huntchat.com
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