Here in Pa we can use a rifle in Fall season only. If I were to use my 222 or 22-250 I'd try for headshots only with a TNT or similiar bullet that blows up on impact. Which means no long range shots. No body shots for me but that's just my preference.
But then wouldn't it also be fun trying it with a flintlock Pa Longrifle.
Good luck and let us know how you make out.