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Yes, what Billy is saying, meaning all the bullets will be seated to various depths inside the case mouth, the longer ones will probably compress most powder charges. The shorter ones will have a longer jump to reach the lands. There are instruments specifically catered to measuring the distance off the lands, but often magazine length is the determining factor in OAL, except for single shots, etc.
One shortcut for a load is do some research and forget trying to develop loads for those bullets that just don't cut it in the caliber you're loading for. Look for common loads and what one considers optimal bullet weights for calibers, i.e., 150-200 for 30-06 means you might just have a bit of trouble trying to get a load for bullets under or over 150-200 grains in that particular caliber. Start with 100 grainers in your .243 and vary from there. Or you might find just what you're looking for right off the bat with the 100 grainers! Waidmannsheil, Dom.
P.S. After reading your post again, the only way they can get such large weight variances and stay .243 caliber is by the length of the bullet. Same principle for other calibers.
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