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Welcome to reloading!
What I try to do is vary my loads (when in the development stage) by .5 grn ie if I'm loading a 35 grn load for a particular bullet I'll load 10 to 15 rnds at 34.5, then 10-15 rnds at 35, then 10-15 rnds at 35.5. Clean my gun, go to the range and set up 4 targets, 1 for fouling shots & 1 for each test group. I usually fire 2 or 3 foulers before settling in to fire for grouping. Wind is your enemy in load development, way to sporadic, I like calm mornings.
Make sure you take time between shots, hey at -6 your barrel cools rapidly! I work with one bullet and one powder at a time, there are already enough variables to worry about. Check out Rocky's Reloading page for further info.
Then it's just a matter of adjusting your loads in the direction which give you the best groupings, until you reach the optimum results.
As far as temp is concerned, some powders are more temperture tolerant than others.
MOA basically says that if you shoot a 1" group at 100 yrds your grouping should then be 2" at 200, 3" at 300 ...etc., for any particular rifle and load. That's my understanding of it anyway.
Good luck with your quest.
MilDot
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