For moose I would definitely go with no less than a 180 grain premium bullet. The Fail Safe has a tendency to plink right on through without opening up much. The last moose I shot was in 2000 and I used a 35 Whelen with 225 grain Barnes. First two shots went on through without much indicated distress on the mooses part. The third shot got the off shoulder and he went down on his side. I ran up and put a finishing shot right behind the head in the spine. End of moose. The impact point of the first three shots could easily be covered by your hand, right behind the left front leg. (Shots meant for the heart). The heart was mush from more than one hit. They can take a lot of killing. He was not totally unaware. He saw me and started to trot to his left, slightly quartering away. After the first shot he jumped a fence a little over 4 feet high with little effort. About two steps on the other side was when No. 2 hit him. He was headed toward a beaver pond and I didn't want him in there. I figured on shooting until I would have to stop to reload. I had one left in the magaine when it was over. Yes, I would use a lead core premium bullet of controlled expansion persuasion.