First off, any load that works well in one rifle may not in yours. I suggest you pick a bullet that weighs 50 to 55 gr. I would go with a solid if you want to save the pelt or a V-Max or the like if you really do not care about the hide. I have had really good luck with Reloader 15 and H380 in the 22-250. Go by the book of the bullet manufacturer on loads!!!! Start low and work up, look for signs of pressure !!!! All that reading is for your safety, Keep getting dizzy