Critch, The Ruger No. 1 is probably the strongest action you can find. I know a lot of folks will be upset, but I would rather have a Ruger No. 1 than any bolt action for strength. If you can take a Ruger No. 1 and make it into a .458 Lott or any of the other large African cartridges, there isn't much to worry about. However, I am sure any enterprizing reloader can exceed the limits of even the Ruger No. 1.
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