IMO, if you reload long enough, and for enough cartridges, you'll run into an issue like is described above. Maybe that's part of what makes reloading so interesting.
I have long tried not to have more than one firearm of the same caliber. For one, that makes fitting your reloads to a specific firearm easier.
Besides, it's always fun to work up a new caliber- if you don't fight it, you often learn something.
