Caliber question

[Larryjk]

My son and son-in-law both shoot in-line 50 caliber muzzle loaders. They are scoped and they use 250 gr. pistol bullets in sabots. They can sit down any time and hit the gongs at 300 yards. I watched my son shoot a coyote in the head (that is all we could see) at about 300 yards. Yes, there was a large gaping hole but it was where the right side of the coyotes head used to be. He wasn't sure he could hit him, but gave it a try.
I have to bear down to hit the 300 yard gong with a 8mm Rem mag.