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Both are excellent calibers. Factory ammo should be available in any gunshop. 243 might be a bit more common at the 'Marts'....
Which one? Depends what you want it for.
I'd get a 243 if I was going to shoot mostly varmints, and the occasional deer or antelope.
If I was going to hunt deer and antelope, with an occasional varmint thrown in, 25-06.
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Jack@huntchat.com
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