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The classic 45 Colt load is 8.0 of Unique - but it was developed with 255 cast bullets. Jacketed bullets will create a bit more pressure but less velocity.
I wouldn't increase beyond 8.0 (especially since you didn't specify what brand of revolver this is) but that should be safe with any modern gun in good condition. If AND ONLY IF this is a Ruger Bisley, Blackhawk or Redhawk, or a Freedom Arms revolver, then we might explore some H110 loads. These are full-power thumpers and shouldn't be used in any other brand or make of gun. Understood? Okay. My friend John Taffin uses 21.0 - 22.0 of H110 under a very hard CAST 300-grain bullet. Cut that to 20.0 for your 250 jacketed XTP. Use a magnum primer with H110, and use an expander ball not over .450" plus a firm crimp. You can reduce this to 18.0 for starters, but no lower, as H110 tends to get squirrely with REDUCED loads.
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