My first 280 was a heavy barrel Ruger 77. It shot every load I tried in accurately. The second 280 was a Mauser 98 7x57 reamed to 280. The fired cases had a slight step on the neck, but caused no problems - it shot Speer magtips very well and was effective on game up to elk. The third 280 is the one I use now. It is the cheapest Remington 700 with plastic stock. After I polished the bore it shoots very well with all loads tried so far. I have only had it long enough to try on antelope. bang flop - the second goat was 440 paces. The first shot on the second goat was too high in the shoulders - above spinal cord. The second shot - bang flop.
I like the 280 and the 30-06 a lot, though I have many rifles with similar size chamberings, 7x57, 270, 308, 280, 30-06, 300 & 338 Win Mag and other from time to time.
If I had one rifle to choose for all the game I go after, it would be either a 30-06 or the 280. If I were to hunt elk more I would go with a heavier caliber, probably 338 but would feel comfortable with the 280 or 30-06.
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